Lose the weight your body has been holding onto.

Compounded semaglutide has the same active ingredient (semaglutide) as the molecule in Ozempic and Wegovy. It is made by licensed U.S. compounding pharmacies selected by your clinician. Compounded medications are not reviewed by the FDA for safety, quality, or efficacy.

WeightlessRx offers physician-supervised compounded GLP-1 weight-loss treatment with two medication options: compounded semaglutide (a GLP-1 receptor agonist, once-weekly injection) and compounded tirzepatide (a dual GLP-1 / GIP receptor agonist, once-weekly injection). Both come with personalized dosing, unlimited clinician messaging, a GLP-1 fitness app, on-demand workouts, meal plans, and 1-on-1 nutrition coaching.

You take a 90-second medical intake, meet with a U.S.-licensed clinician via telehealth, and — if clinically appropriate — your prescription ships free in discreet packaging from a licensed U.S. compounding pharmacy. You get unlimited messaging with your clinician, titration guidance, proactive side-effect support, and access to the WeightlessRx app (workouts, meal plans, nutrition coach). Refills ship on a set cadence and your clinician follows up between them.

WeightlessRx is available in 49 U.S. states. We currently do not serve Mississippi. Prescriptions are written by U.S.-licensed clinicians in your state of residence and shipped nationwide from our partner compounding pharmacy.

Within minutes of completing your intake, a clinician reviews your medical history. If approved, your first dose of compounded semaglutide or tirzepatide ships within 3–5 business days. You will get onboarded into the WeightlessRx app, paired with your clinician for messaging, and scheduled for your first follow-up. Most members feel reduced food noise within 7–14 days and begin losing weight by week 4.

No. WeightlessRx is a cash-pay telehealth service, so there are no insurance requirements, no prior authorizations, and no surprise bills. Our prices are flat. Most members use HSA or FSA funds, and we provide a superbill on request for out-of-network reimbursement.

Semaglutide starts at $167/month (billed quarterly at $500 every 3 months). Tirzepatide starts at higher dosing tiers based on your clinical protocol. There is no membership fee, no consult fee, and shipping is free. Compare full pricing on the plans section above.

You can cancel any subscription at any time with no cancellation fee. Cancellation requests must be submitted at least 5 business days before your next billing date to stop the upcoming charge — requests received within 5 days of billing will apply to the following cycle. To cancel, email info@weightlessrx.com or text +1 (307) 441-3679. Due to federal law (21 CFR §203.23), prescription medications are non-refundable once dispensed, and consultation fees are non-refundable once your clinical review begins.

Cancel by emailing info@weightlessrx.com or texting +1 (307) 441-3679 at least 5 business days before your next billing date. Include your full name and the email on your account. You will receive a confirmation once your cancellation is processed, and you will keep access to services through the end of your current billing period.

Yes. You can pause your WeightlessRx subscription for up to 90 days. During the pause, you will not be billed and your access to services is temporarily suspended. Email info@weightlessrx.com or text +1 (307) 441-3679 to request a pause at least 5 business days before your next billing date.

Most members notice reduced food noise and appetite within 7–14 days and begin losing weight by week 4. Average loss at 6 months ranges from 12–18% of body weight on semaglutide and 18–24% on tirzepatide, depending on dose and adherence. Your clinician adjusts your protocol based on how you respond.

The most common side effects are mild nausea, constipation, diarrhea, fatigue, or reflux during the first 2–4 weeks as your body adjusts. These typically resolve as dosing stabilizes. Serious but rare side effects include pancreatitis, gallbladder issues, and thyroid C-cell tumors — these medications carry a boxed warning for medullary thyroid carcinoma (MTC). Your clinician will review the full list with you and manage side effects proactively between refills.

GLP-1 medications are not appropriate for people with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN 2), a history of pancreatitis, severe gastrointestinal disease, or active eating disorders, and are not used during pregnancy or breastfeeding. Your clinician screens for all of this during your medical intake.

Often yes. If you are transitioning from Ro, Mochi, TrimRx, Hims, or another GLP-1 program, share your current medication, dose, and how long you have been on it in your intake. Your WeightlessRx clinician can continue you at or near your current titration level when clinically appropriate, so you do not have to restart from week one.

Yes. Many members start on compounded semaglutide and move to tirzepatide for stronger results, or step down from tirzepatide to semaglutide for maintenance. Your clinician coordinates the switch, adjusts your dose, and manages the transition so you do not lose momentum.

WeightlessRx is a LegitScript-certified telehealth service that connects patients with independent, U.S.-licensed clinicians. All prescriptions are issued only when clinically appropriate and dispensed by licensed U.S. pharmacies. We operate in full HIPAA compliance, partner with VitaScripts Pharmacy, and comply with the Prescription Drug Marketing Act (21 CFR Parts 203 & 205) and state telehealth regulations.

Every member has unlimited messaging with their prescribing clinician inside the WeightlessRx app. If you experience side effects, your clinician responds quickly with dose adjustments, anti-nausea strategies, or hydration guidance. For billing or account issues, support is reachable by email (info@weightlessrx.com) or text (+1 307-441-3679) Monday–Friday. For medical emergencies, always call 911.

The injection is subcutaneous (just under the skin), given once weekly in the stomach, thigh, or upper arm with a small insulin-style needle that most members barely feel. Your first shipment includes a step-by-step injection guide and video walkthrough, and your clinician is available by message if you want to be walked through your first dose live.

Your medication ships free from our partner compounding pharmacy in discreet, temperature-controlled packaging with cold packs when required. Store the vial in the refrigerator (36–46°F / 2–8°C), protected from light. Never freeze the medication. Each shipment includes supplies (syringes, alcohol wipes, sharps-disposal instructions) so you have everything you need.

If you are not losing weight as expected, your clinician will review your protocol — often that means titrating up, switching from semaglutide to tirzepatide, or adjusting your nutrition plan with your coach. No two bodies respond the same. We do not charge more for these adjustments; active optimization is part of your plan.

WeightlessRx includes everything most GLP-1 telehealth programs charge extra for: a GLP-1 fitness app, on-demand workouts, personalized meal plans, 1-on-1 nutrition coaching, recipe library, and direct clinician messaging — with no membership fee. Ro Body charges $145/month membership, Mochi Health $79/month, TrimRx $99/month, and Hims $69/month on top of medication. See the full comparison above.

Yes. WeightlessRx medical consultations and compounded GLP-1 prescriptions are HSA-eligible and FSA-eligible. Most members pay with their HSA or FSA card at checkout. We also provide an itemized superbill on request if your plan requires one for reimbursement.